Description

Vasoactive Intestinal Peptide, Iodo-Tyr(10)-Met Sulfoxide(17)- CAS NO 98575-84-9 is a chemically modified, radiolabeled analog of the endogenous 28-amino acid neuropeptide, Vasoactive Intestinal Peptide (VIP). This compound is specifically engineered for research applications, featuring an iodine label at the tyrosine-10 position and a methionine sulfoxide modification at position 17. It is a critical tool for scientists investigating VIP receptor (VPAC1/VPAC2) binding, distribution, and function in physiological and pathological states. This high-purity peptide is primarily utilized in pharmaceutical R&D, neuroendocrine research, and the development of diagnostic imaging agents.

Application

• Receptor Binding Assays & Autoradiography: Used as a radioligand for the quantitative study of VIP receptor density, affinity (Kd), and distribution in tissue sections and cell membranes.
• Pharmacological Research: Serves as a key reagent in competitive binding studies to screen and characterize novel VPAC1/VPAC2 receptor agonists and antagonists.
• Molecular Imaging Probe Development: Acts as a precursor or model compound for developing targeted imaging agents for conditions like cancer, inflammation, and neurodegenerative diseases.
• Metabolic & Signal Transduction Studies: Employed to trace and elucidate the internalization, metabolic fate, and downstream signaling pathways activated by VIP receptor engagement.
• Quality Control & Standardization: Used as a reference standard in the quality control of VIP-related pharmaceutical products and in vitro diagnostic (IVD) kits.
• Academic & Institutional Research: Fundamental research tool in neuroscience, endocrinology, and immunology to understand VIP's role in vasodilation, secretion, and immune modulation.

Basic Information

Item	Detail
Product Name	Vasoactive Intestinal Peptide, Iodo-Tyr(10)-Met Sulfoxide(17)- CAS NO 98575-84-9
CAS No.	98575-84-9
Molecular Formula	C147H238N42O44SI
Molecular Weight	~3326.7 g/mol
Synonyms	VIP, Iodo-Tyr10, Met(O)17; [Iodo-Tyrosine10, Methionine Sulfoxide17]-Vasoactive Intestinal Peptide; Iodinated VIP Analog; VIP (Iodo-Tyr10, Met(O)17); Radiolabeled VIP Derivative; VPAC Receptor Ligand; Vasoactive Intestinal Polypeptide Iodo Derivative
EINECS	Contact for details

Quality Control

This peptide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC for purity assessment and Mass Spectrometry (MS) for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and specific analytical data is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.