Description

Proline, 4,5,5-Trimethyl- (6Ci) is a specialized, non-proteinogenic derivative of the amino acid proline, characterized by its unique alkyl substitution pattern on the pyrrolidine ring. This structural modification imparts distinct steric and electronic properties, making it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research institutions and industrial R&D departments focused on pharmaceutical development, agrochemicals, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators where its modified proline scaffold can influence biological activity.
• Peptidomimetics & Drug Design: Incorporated into peptide analogs to enhance metabolic stability, modify conformation, and improve binding affinity to biological targets.
• Asymmetric Catalysis: Employed as a precursor for designing novel chiral ligands and organocatalysts used in stereoselective chemical transformations.
• Biochemical Research: Utilized as a probe or standard in metabolic studies and enzyme inhibition assays to understand biological pathways.
• Fine Chemical Synthesis: Acts as a versatile intermediate for the production of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	Proline, 4,5,5-Trimethyl- (6Ci)
CAS No.	98552-65-9
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	4,5,5-Trimethylproline; 4,5,5-Trimethyl-L-proline (if stereospecific); 4,5,5-Trimethyl-2-pyrrolidinecarboxylic acid; 2-Pyrrolidinecarboxylic acid, 4,5,5-trimethyl-; (S)-4,5,5-Trimethylproline; 4,5,5-Trimethyl-DL-proline; NSC 163063
EINECS	Contact for details

Quality Control

Our Proline, 4,5,5-Trimethyl- (6Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing identity, purity (by HPLC), and specific parameters is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiomerically pure grade)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.