Description

Dermorphin, Arg(2)-Gly(3)-Phe(4)- is a synthetic heptapeptide analog of the potent natural opioid peptide dermorphin. This compound is of significant interest in advanced biochemical and pharmacological research due to its high affinity and selectivity for mu-opioid receptors. It is primarily utilized by research institutions and pharmaceutical development teams focused on neurobiology, pain management pathways, and novel analgesic discovery. The product is supplied as a high-purity material suitable for critical laboratory and pre-clinical applications.

Application

• Neuroscience Research: Investigation of mu-opioid receptor (MOR) signaling, binding affinity studies, and neuronal pathway analysis.
• Analgesic Drug Discovery: Serving as a reference standard or lead compound in the development of new, potent pain-relief medications with potentially reduced side-effect profiles.
• Biochemical Assay Development: Use in competitive binding assays (e.g., radioimmunoassays, fluorescence polarization) to screen for new receptor ligands or antagonists.
• Structure-Activity Relationship (SAR) Studies: As a core scaffold for chemical modification to understand the pharmacophore and optimize peptide stability, potency, and selectivity.
• In Vitro & Ex Vivo Pharmacological Testing: Evaluation of physiological responses in tissue cultures or isolated organ preparations.
• Reference Material: Use as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Dermorphin, Arg(2)-Gly(3)-Phe(4)-
CAS No.	98495-22-8
Molecular Formula	C₄₀H₅₈N₁₂O₁₀
Molecular Weight	854.98 g/mol
Synonyms	H-Tyr-D-Arg-Phe-Gly-Tyr-Pro-Ser-NH₂; [D-Arg2, Phe4]-Dermorphin (1-7); Dermorphin (1-7) amide, [D-Arg2, Phe4]-; Arg-Phe-Gly-Tyr-Pro-Ser-NH2 (sequence with D-Arg at position 2); Tyr-D-Arg-Phe-Gly-Tyr-Pro-Ser-NH2; Dermorphin heptapeptide analog; Mu-opioid receptor selective peptide; [D-Arg2, Phe4]-Dermorphin-NH2
EINECS	Contact for details

Quality Control

Our Dermorphin, Arg(2)-Gly(3)-Phe(4)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Standard specifications align with research-grade peptide standards, with purity typically verified by HPLC and structural confirmation by Mass Spectrometry (MS). A detailed Certificate of Analysis (COA) providing batch-specific results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere. Keep containers tightly sealed in a dry, cool place.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.