Description

Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn CAS NO 98474-59-0 is a synthetic peptide sequence, also known as a fragment of the human parathyroid hormone (PTH). This compound is of significant value in biochemical and pharmaceutical research due to its role in studying calcium metabolism and bone physiology. It is primarily needed by research institutions, biotechnology companies, and pharmaceutical developers focused on metabolic disorders, osteoporosis research, and peptide-based therapeutic discovery.

Application

• Biochemical Research: Used as a reference standard and active fragment in studies of parathyroid hormone (PTH) receptor binding and signal transduction pathways.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) precursor in the development of novel therapeutics for bone diseases like osteoporosis and hyperparathyroidism.
• Diagnostic Reagent Production: Employed in the formulation of immunoassays and diagnostic kits for measuring PTH levels in clinical and research settings.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the effects of PTH on osteoblast and osteoclast activity.
• Peptide Chemistry & Conjugation: Acts as a substrate for further chemical modification, labeling, or conjugation in proteomics and drug delivery system research.

Basic Information

Product Name	Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn
CAS No.	98474-59-0
Molecular Formula	C73H118N24O26
Molecular Weight	1651.88 g/mol
Synonyms	PTH (1-15); Human Parathyroid Hormone (1-15); H-PTH(1-15)-OH; Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH; Parathyroid Hormone Fragment 1-15; PTH 1-15 Amide (common reference); Acetyl-PTH(1-15)-amide (related derivative)
EINECS	Contact for details

Quality Control

Our Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (AAA)	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.