Description

Proline, 4-(1-Methylethenyl)- (9Ci) is a specialized proline derivative characterized by an isopropenyl substituent on the pyrrolidine ring. This structural modification makes it a valuable non-proteinogenic amino acid building block for advanced organic synthesis and pharmaceutical research. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel peptide mimetics, chiral catalysts, and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other peptide-based therapeutics.
• Peptidomimetic Design: Used to introduce conformational constraints and lipophilic side chains into peptide analogs, enhancing their metabolic stability and binding affinity.
• Agrochemical Research: Employed in the synthesis of novel chiral compounds with potential herbicidal or insecticidal activity.
• Catalyst Ligand Synthesis: Acts as a precursor for creating sophisticated chiral ligands used in asymmetric catalysis.
• Biochemical Research: Utilized as a probe or standard in studies of amino acid metabolism and enzyme specificity.
• Fine Chemical Synthesis: A versatile building block for the preparation of complex natural product analogs and specialty chemicals.

Basic Information

Product Name	Proline, 4-(1-Methylethenyl)- (9Ci)
CAS No.	98426-30-3
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	4-Isopropenylproline; 4-(Prop-1-en-2-yl)proline; (4R)-4-(1-Methylethenyl)-L-proline; 4-Vinylidene-proline; L-Proline, 4-(1-methylethenyl)-; 4-(1-Methylethenyl)-L-proline; 98426-30-3; 4-(Prop-1-en-2-yl)-L-proline
EINECS	Contact for details

Quality Control

Our Proline, 4-(1-Methylethenyl)- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.