Description

Pyroglutamyl-Leucyl-Tryptophan Methyl Ester is a synthetic tripeptide derivative, specifically a pyroglutamate-modified peptide methyl ester. This compound is of significant interest in advanced pharmaceutical research and development, particularly in the design of peptide-based therapeutics and bioactive probes. It serves as a key intermediate or reference standard for researchers in medicinal chemistry, biochemistry, and peptide synthesis targeting neurological and metabolic pathways.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel peptide drugs and therapeutic candidates.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies and receptor-ligand interaction assays.
• Medicinal Chemistry: Serves as a core structure for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties.
• Cosmeceutical Development: Investigated for potential bioactive properties in advanced skincare formulations targeting specific cellular pathways.
• Neuroscience Research: Potential tool compound for studying neuropeptide analogs and their effects.
• Process Development: Used in scaling up and optimizing synthetic routes for complex peptide manufacturing.

Basic Information

Product Name	Pyroglutamyl-Leucyl-Tryptophan Methyl Ester
CAS No.	98385-67-2
Molecular Formula	C22H28N4O5
Molecular Weight	428.48 g/mol
Synonyms	pGlu-Leu-Trp-OMe; 5-Oxo-L-prolyl-L-leucyl-L-tryptophan methyl ester; L-Pyroglutamyl-L-leucyl-L-tryptophan methyl ester; Pyr-Leu-Trp-OMe; Methyl N-[(2S)-1-[[(2S)-1-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]-4-methylpentan-2-yl]amino]-1-oxo-3-(1H-indol-3-yl)propan-2-yl]carbamate; 5-Oxoprolylleucyltryptophan methyl ester; N-pGlu-Leu-Trp-OMe
EINECS	Contact for details

Quality Control

Our Pyroglutamyl-Leucyl-Tryptophan Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via mass spectrometry and IR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.