Description

(2S)-2-Amino-3-[1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazol-4-yl]propanoic acid is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced biochemical research and pharmaceutical development. Its core value lies in its unique structure, which combines an imidazole ring with a ribose-like moiety, making it a critical intermediate for synthesizing nucleoside analogs and enzyme inhibitors. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly those focused on antiviral drug discovery, metabolic pathway studies, and the development of novel therapeutic agents. CAS No. 98379-91-0.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel nucleoside analog prodrugs with potential antiviral or anticancer activity.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving histidine biosynthesis or purine metabolism pathways.
• Proteomics & Peptide Chemistry: Incorporated into synthetic peptides to study protein structure-function relationships or to create peptides with modified biological properties.
• Diagnostic Reagent Development: Serves as a precursor for fluorescent or labeled compounds used in diagnostic assays and imaging probes.
• Enzyme Mechanism Studies: Employed to investigate the catalytic mechanisms of transferases and synthetases that utilize similar histidine-containing substrates.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting fundamental research in medicinal chemistry and chemical biology.

Basic Information

Product Name	(2S)-2-Amino-3-[1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazol-4-yl]propanoic Acid
CAS No.	98379-91-0
Molecular Formula	C11H17N3O6
Molecular Weight	287.27 g/mol
Synonyms	L-Histidine, 1-(β-D-ribofuranosyl)-; 1-(β-D-Ribofuranosyl)-L-histidine; L-1-(β-D-Ribofuranosyl)histidine; Histidine Ribonucleoside; 1-Ribosyl-L-histidine; NSC 401005; (S)-2-Amino-3-(1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-imidazol-4-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our (2S)-2-Amino-3-[1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazol-4-yl]propanoic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain purity and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.