Description

Leucine, 3-Mercapto- (6Ci,9Ci) is a specialized sulfur-containing derivative of the essential amino acid L-leucine. This compound matters as a versatile chiral building block and intermediate, offering unique reactivity due to the presence of both an amino acid backbone and a thiol functional group. It is primarily needed by research and development chemists in the pharmaceutical and fine chemical industries for applications in peptide synthesis, drug discovery, and the development of novel biochemical tools.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting metabolic or neurological pathways.
• Peptide Chemistry: Used in the synthesis of modified peptides where the thiol side chain enables disulfide bridge formation or conjugation with other molecules.
• Biochemical Research: Acts as a precursor or standard in studies involving sulfur amino acid metabolism, enzyme inhibition, or as a ligand for metal coordination.
• Fine Chemical Synthesis: Employed as a building block for creating complex organic molecules, flavors, or fragrances that require a specific leucine-derived stereochemistry with added thiol functionality.
• Material Science: Investigated for potential use in the development of functionalized surfaces or polymers where the thiol group provides a handle for attachment.

Basic Information

Product Name	Leucine, 3-Mercapto- (6Ci,9Ci)
CAS No.	98278-26-3
Molecular Formula	C6H13NO2S
Molecular Weight	163.24 g/mol
Synonyms	3-Mercaptoleucine; 3-Thioleucine; 2-Amino-4-methylpentane-1-thiol-3-carboxylic acid; β-Mercaptoleucine; (3R)-3-Mercaptoleucine; L-3-Mercaptoleucine; 3-Mercapto-L-leucine; 3-Thio-L-leucine
EINECS	Contact for details

Quality Control

Our Leucine, 3-Mercapto- (6Ci,9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), chiral purity, and related substances. While typically supplied as a research-grade material, production can be aligned with cGMP guidelines for advanced development purposes upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive). Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.