Description

5-Chloro-6-Methoxy-5,6-Dihydrothymine is a specialized heterocyclic organic compound that serves as a crucial synthetic intermediate in advanced pharmaceutical research and development. Its unique halogenated dihydrothymine structure makes it a valuable building block for the synthesis of novel nucleoside analogs and active pharmaceutical ingredients (APIs). This high-purity intermediate is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries working on antiviral, anticancer, and other therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug candidates.
• Agrochemical Research: Used in the development of new herbicides and plant growth regulators that target specific biochemical pathways.
• Biochemical Tool Compound: Serves as a substrate or inhibitor in enzymatic studies related to thymine metabolism and DNA repair mechanisms.
• Fine Chemical Synthesis: Intermediate for creating complex molecules with potential biological activity in medicinal chemistry programs.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological development and exploratory synthetic chemistry.

Basic Information

Product Name	5-Chloro-6-Methoxy-5,6-Dihydrothymine
CAS No.	98140-01-3
Molecular Formula	C6H9ClN2O3
Molecular Weight	192.60 g/mol
Synonyms	5-Chloro-6-methoxy-5,6-dihydro-2,4(1H,3H)-pyrimidinedione; 5-Chloro-6-methoxydihydrothymine; 5-Chloro-6-methoxy-5,6-dihydrouracil; 6-Methoxy-5-chloro-5,6-dihydrothymine; 5-Chloro-6-methoxy-5,6-dihydro-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione (methylated derivative); Thymine, 5-chloro-6-methoxy-5,6-dihydro-; 98140-01-3
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Methoxy-5,6-Dihydrothymine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity determination and NMR/IR for structural confirmation. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.