Description

Substance P, Gly(12)-Lys(13)- is a specific, biologically active peptide fragment derived from the full Substance P neuropeptide. This compound is of significant value for research into neurokinin-1 (NK1) receptor interactions and signal transduction pathways. It is primarily needed by biochemical and pharmaceutical research laboratories for use as a critical reference standard and tool compound in neuroscience, pharmacology, and drug discovery applications. The CAS number for this material is 98093-86-8.

Application

• Neuroscience Research: Used as a precise tool to study the structure-activity relationship (SAR) of Substance P and its binding affinity to the NK1 receptor.
• Pharmacological Studies: Serves as a key reference standard in assays designed to screen for NK1 receptor antagonists and modulators.
• Biochemical Reagent: Employed in enzymatic digestion studies and peptide mapping to understand Substance P metabolism and degradation.
• Drug Discovery & Development: Acts as a critical intermediate or analog in the design and synthesis of novel neuropeptide-based therapeutics.
• Cell Signaling Research: Utilized to investigate intracellular pathways activated by specific Substance P fragments in various cell types.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes focusing on neuropeptide biology and peptide chemistry.

Basic Information

Product Name	Substance P, Gly(12)-Lys(13)-
CAS No.	98093-86-8
Molecular Formula	C~36~H~62~N~12~O~9~
Molecular Weight	806.96 g/mol
Synonyms	Substance P (6-11), amide; Substance P Fragment 6-11; [Gly12,Lys13]-Substance P (6-11); Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (6-11 fragment analog); Neurokinin P (6-11) fragment; SP (6-11); H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (modified); Tachykinin fragment
EINECS	Contact for details

Quality Control

Our Substance P, Gly(12)-Lys(13)- is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research purposes. Each lot is characterized using advanced analytical techniques, including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.