Description

Substance P, Gly(12)- CAS NO 98093-85-7 is a synthetic peptide analog of the neuropeptide Substance P, specifically modified with a glycine residue at position 12. This modification is crucial for enhancing its stability and specificity in research applications, making it a valuable tool for studying neurokinin-1 (NK-1) receptor interactions. It is primarily utilized by researchers and developers in the pharmaceutical and life sciences sectors for neuropharmacology studies, receptor binding assays, and the development of novel therapeutic agents targeting pain and inflammatory pathways.

Application

• Neuroscience Research: A key reagent for studying the role of Substance P in pain transmission, neurogenic inflammation, and central nervous system signaling.
• Receptor Binding & Characterization: Used in competitive binding assays to characterize and quantify NK-1 receptor affinity and density.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening programs for novel analgesics and anti-inflammatory drugs.
• Cell Signaling Studies: Employed to investigate intracellular signaling cascades and cellular responses mediated by tachykinin receptors.
• Biochemical Assay Standard: Acts as a calibrated standard in HPLC, MS, and other analytical methods for peptide quantification and purity assessment.

Basic Information

Product Name	Substance P, Gly(12)- CAS NO 98093-85-7
CAS No.	98093-85-7
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.6 g/mol
Synonyms	[Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-Gly-NH2]; Substance P (5-11), Gly(12)-; [Gly12]-Substance P; Neurokinin P; Tachykinin; SP (5-11) Gly12 amide; Substance P fragment 5-11 with C-terminal Glycine amide
EINECS	Contact for details

Quality Control

Our Substance P, Gly(12)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specifications to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.