Description

3-Quinolinecarboxylic Acid, 1-Ethyl-6,8-Difluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-, (S)- is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound is a key chiral building block in the synthesis of modern fluoroquinolone antibiotics, valued for its precise stereochemistry and functional group arrangement. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers engaged in the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Critical chiral synthon for the synthesis of advanced fluoroquinolone antibiotic APIs, such as levofloxacin and its derivatives.
• Antibacterial Drug Development: Serves as a core structural component in research for novel broad-spectrum antibacterial agents targeting DNA gyrase and topoisomerase IV.
• Organic Synthesis Research: Used in academic and industrial research to study structure-activity relationships (SAR) in quinolone chemistry and to develop new synthetic methodologies.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale production runs for established antibiotic manufacturing pathways.
• Reference Standard: Can be utilized as a high-purity chemical reference standard (CRS) for analytical method development and quality control in API production.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Ethyl-6,8-Difluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-, (S)-
CAS No.	98079-62-0
Molecular Formula	C17H19F2N3O3
Molecular Weight	351.35 g/mol
Synonyms	(S)-(-)-Ofloxacin Intermediate; Levofloxacin Intermediate; (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid; (3S)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid; (S)-(-)-DR-3355; (S)-Ofloxacin; (-)-Ofloxacin; Levofloxacin Carboxylic Acid Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 1-Ethyl-6,8-Difluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-, (S)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent specifications required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, impurity profile, and residual solvents are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% (S)-isomer
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.