Description

(R)-Lomefloxacin Hydrochloride CAS NO 98079-56-2 is the single enantiomer form of the broad-spectrum fluoroquinolone antibiotic lomefloxacin. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereospecific drug activity and the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced antimicrobial research, chiral synthesis, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure fluoroquinolone antibiotics.
• Antimicrobial Research: Used in biochemical and microbiological studies to investigate the stereospecificity of antibiotic action and bacterial resistance mechanisms.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development and quality control in pharmaceutical labs.
• Chiral Catalyst/ Ligand Study: Employed in research exploring novel chiral catalysts or ligands in asymmetric synthesis.
• Metabolism and Pharmacokinetics: Utilized in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the biological fate of the (R)-enantiomer.
• Impurity Profiling: Acts as a critical marker for identifying and quantifying the undesired enantiomer in the production of the active (S)-lomefloxacin.

Basic Information

Product Name	(R)-Lomefloxacin Hydrochloride
CAS No.	98079-56-2
Molecular Formula	C17H19F2N3O3 • HCl
Molecular Weight	387.81 g/mol
Synonyms	(R)-Lomefloxacin HCl; (-)-(R)-Lomefloxacin Hydrochloride; (R)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Hydrochloride; (R)-Lomefloxacin Monohydrochloride; (R)-Lomefloxacin Hydrochloride Salt; UNII-9K4H8S5FQI; (R)-Lomefloxacin HCL; (R)-Enantiomer of Lomefloxacin Hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Lomefloxacin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing identity, purity, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.