Description

Boc-Pro-Pna CAS NO 97885-49-9 is a protected amino acid derivative, specifically N-(tert-Butoxycarbonyl)-L-proline p-nitroanilide, widely used as a key synthetic intermediate and biochemical reagent. Its primary value lies in providing a versatile, orthogonally protected proline moiety for the controlled synthesis of peptides and peptidomimetics, crucial for research and development. This compound is essential for pharmaceutical R&D laboratories, academic institutions, and fine chemical manufacturers focused on protease substrate studies, inhibitor design, and advanced peptide chemistry.

Application

• Peptide Synthesis Intermediate: Serves as a critical building block for introducing proline residues in solid-phase and solution-phase peptide synthesis.
• Protease Substrate & Inhibitor Development: Used in the design and synthesis of chromogenic and fluorogenic substrates for studying protease enzyme kinetics and screening inhibitors.
• Biochemical Research Reagent: Employed in academic and industrial research for investigating proline-specific enzymatic cleavage and protein-protein interactions.
• Pharmaceutical Active Ingredient (API) Development: Acts as a precursor in the synthetic pathways of drug candidates targeting various diseases.
• Combinatorial Chemistry Libraries: Utilized as a diversified scaffold for generating focused libraries in drug discovery programs.

Basic Information

Product Name	Boc-Pro-Pna
CAS No.	97885-49-9
Molecular Formula	C₁₆H₂₁N₃O₅
Molecular Weight	335.36 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-proline p-nitroanilide; Boc-L-Proline 4-nitroanilide; Boc-Pro-pNA; (S)-2-((tert-Butoxycarbonyl)amino)-1-(4-nitrophenylamino)-1-oxopentane; N-Boc-L-proline p-nitroanilide; tert-Butyloxycarbonyl-L-proline p-nitroanilide; Boc-Pro-4-NA; L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-, 4-nitroanilide
EINECS	Contact for details

Quality Control

Our Boc-Pro-Pna is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for pharmaceutical intermediates or biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.