Description

Glucagon, Carboxy-Me-Met(27)- is a chemically modified derivative of the peptide hormone glucagon, specifically methylated at the methionine residue at position 27. This modification is crucial for enhancing the compound's stability and biological activity in research and development settings. It is primarily utilized by pharmaceutical researchers and biotech companies engaged in metabolic disorder studies, diabetes research, and the development of novel peptide-based therapeutics.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active ingredient in the development of novel glucagon analogs for treating hypoglycemia.
• Metabolic Disorder Studies: Used in preclinical and clinical research to investigate glucagon receptor signaling, hepatic glucose production, and energy metabolism.
• Biochemical Assay Development: Employed as a critical component in the development and validation of immunoassays (ELISA, RIA) and bioassays for glucagon activity.
• Peptide Chemistry & Stability Studies: Acts as a model compound for studying the effects of specific amino acid modifications (carboxy-methylation) on peptide stability, solubility, and receptor binding affinity.
• Academic Research: Utilized in university and institutional labs for fundamental research into endocrinology, peptide hormone action, and diabetes pathophysiology.

Basic Information

Product Name	Glucagon, Carboxy-Me-Met(27)-
CAS No.	97837-44-0
Molecular Formula	C153H225N43O49S
Molecular Weight	3484.7 g/mol
Synonyms	Carboxymethyl-Met(27)-Glucagon; [Carboxymethyl-Met27]Glucagon; Glucagon (1-29), 27-Met-carboxymethyl-; Glucagon derivative; Modified glucagon peptide; Hypoglycemic agent analog; Glucagon analog; Peptide hormone derivative
EINECS	Contact for details

Quality Control

Our Glucagon, Carboxy-Me-Met(27)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and peptide content determination. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (UV)	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.