Description

(β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin is a synthetic, biologically active peptide analog of bradykinin, a potent vasoactive nonapeptide. This modified sequence, featuring specific amino acid substitutions including a thienylalanine residue, is designed for enhanced receptor selectivity and metabolic stability in research applications. It serves as a critical pharmacological tool for scientists in the life sciences sector, particularly those investigating the kallikrein-kinin system, inflammation, pain pathways, and cardiovascular physiology. The compound is essential for high-purity biochemical research and preclinical development.

Application

• Pharmacological Research: Used as a selective ligand to study bradykinin B1 and B2 receptor subtypes, their signaling pathways, and physiological roles.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel anti-inflammatory, analgesic, or cardiovascular therapeutics.
• Biochemical Assays: Employed in competitive binding assays, receptor characterization studies, and enzyme inhibition tests to determine potency and selectivity.
• Academic & Institutional Research: A key reagent for investigating the role of kinins in conditions like sepsis, hypertension, neuropathic pain, and angioedema.
• In Vitro & Ex Vivo Studies: Applied in cell-based assays and tissue bath experiments to study vascular tone, smooth muscle contraction, and inflammatory mediator release.
• Metabolic Stability Studies: The structural modifications make it a useful compound for studying peptide degradation and designing metabolically stable analogs.

Basic Information

Product Name	(β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin
CAS No.	97825-07-5
Molecular Formula	C58H75N13O11S2
Molecular Weight	1186.4 g/mol
Synonyms	Bradykinin, [Tic5,8, D-Phe7]-; [β-(2-Thienyl)-Ala5,8,D-Phe7]-Bradykinin; (Tic5,8, D-Phe7)-Bradykinin; H-Arg-Pro-Pro-Gly-Phe-Tic-Pro-D-Phe-Tic-Arg-OH; Bradykinin B2 Receptor Antagonist Analog; Thiophan; Thiophan BK; Des-Arg9-[Tic5,8, D-Phe7]-Bradykinin (common misnomer)
EINECS	Contact for details

Quality Control

Our (β-(2-Thienyl)-Ala5,8,D-Phe7)-Bradykinin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.