Description

Vasopressin, 1-Desamino-(8-Rhodamine-Lys)- is a synthetic, fluorescently labeled analog of the neurohypophysial hormone vasopressin, where a rhodamine dye is conjugated to a lysine residue at position 8. This compound is specifically engineered for advanced research applications, offering a powerful tool for visualization and tracking. It is primarily utilized by researchers and developers in the fields of pharmacology, neurobiology, and biomedical diagnostics who require precise molecular probes. The product is supplied to exacting standards to ensure reliable performance in sensitive experimental settings.

Application

• Fluorescent Receptor Binding Assays: Used as a high-affinity, traceable ligand for studying vasopressin receptor (V1a, V1b, V2) localization and density.
• Cellular Imaging and Trafficking Studies: Enables real-time visualization of receptor internalization and intracellular pathway activation in live or fixed cells.
• High-Throughput Screening (HTS): Serves as a key reagent in drug discovery platforms to identify and characterize novel vasopressin receptor agonists or antagonists.
• Biomarker Research: Facilitates the development of diagnostic assays for conditions related to vasopressin pathway dysregulation.
• Neuroscience Research: Critical for mapping vasopressinergic pathways in the brain and understanding their role in social behavior, stress response, and water homeostasis.
• Method Development: Used as a standard or reference compound in the development and validation of new analytical techniques like fluorescence polarization or microscopy protocols.

Basic Information

Product Name	Vasopressin, 1-Desamino-(8-Rhodamine-Lys)-
CAS No.	97813-21-3
Molecular Formula	C76H105N19O19S2 (Representative)
Molecular Weight	~1640.9 g/mol (Theoretical)
Synonyms	[8-Lys(Rhodamine)]-desmopressin; 1-Deamino-8-D-arginine vasopressin, 8-Lys(Rhodamine)-; dDAVP, 8-Lys(Rhodamine)-; Fluorescent dDAVP; Rhodamine-labeled Vasopressin analog; AVPR2 fluorescent ligand; (2-S)-1-[(4R,7S,10S,13S,16R,19S)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(1R)-1-carboxy-2-(4-hydroxyphenyl)ethyl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]-5-[[5-[[6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl]benzoyl]amino]pentyl]amino]-5-oxopentan-2-aminium
EINECS	Contact for details

Quality Control

Our Vasopressin, 1-Desamino-(8-Rhodamine-Lys)- is produced and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research use. Certificates of Analysis (COA) detailing purity, spectral data, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Red to purple solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Fluorescence Properties	Ex/Em maxima consistent with Rhodamine label

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.