Description

Parathyroid Hormone (43-68), 68-Tyr- is a synthetic peptide fragment corresponding to the C-terminal region of the human parathyroid hormone (PTH). This compound is a critical research tool for investigating the structure-activity relationships and biological functions of PTH, particularly its role in calcium and phosphate metabolism. It is essential for researchers and developers in the fields of endocrinology, bone metabolism, and peptide-based pharmaceutical development.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of PTH receptor binding, signal transduction, and calcium homeostasis.
• Pharmaceutical R&D: Serves as a key intermediate or starting material in the development of novel therapeutics for osteoporosis and other bone disorders.
• Diagnostic Development: Employed in the development and calibration of immunoassays (e.g., ELISA) to detect and quantify PTH or related peptides.
• Structure-Activity Relationship (SAR) Studies: Crucial for mapping the bioactive regions of the full-length PTH hormone to design potent analogs or antagonists.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to study the effects of PTH fragments on osteoblast and osteoclast activity.

Basic Information

Product Name	Parathyroid Hormone (43-68), 68-Tyr-
CAS No.	97642-75-6
Molecular Formula	C₁₄₀H₂₂₀N₄₂O₄₃
Molecular Weight	3184.5 g/mol (approximate)
Synonyms	PTH (43-68), 68-Tyr-; Parathyroid Hormone Fragment (43-68), 68-Tyr-; H-Tyr-Val-Asp-Leu-Ile-Lys-Gln-Leu-Ser-Ala-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH; PTHrP (43-68) analog; C-terminal Parathyroid Hormone peptide; CAS 97642-75-6
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (43-68), 68-Tyr- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided, reporting data from HPLC, MS, and amino acid analysis. We support research and development requiring materials produced with GMP-like controls for reliable and reproducible results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.