Description

Parathyroid Hormone (42-55), 55-Tyr- CAS NO 97613-65-5 is a specific, biologically active fragment of the parathyroid hormone (PTH). This synthetic peptide is of significant value for research and development due to its role in calcium and phosphate metabolism. It is primarily utilized by biopharmaceutical companies and academic research institutions focused on bone biology, endocrine disorders, and peptide-based therapeutic discovery.

Application

• Biomedical Research: Used as a critical reference standard and active agent in studies of calcium homeostasis, bone remodeling, and parathyroid hormone receptor (PTH1R) signaling pathways.
• Drug Discovery & Development: Serves as a key intermediate or pharmacophore in the design and screening of novel therapeutics for osteoporosis, hypoparathyroidism, and chronic kidney disease-mineral and bone disorder (CKD-MBD).
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to detect PTH or related fragments in clinical samples.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the bioactive regions of parathyroid hormone to understand and enhance peptide stability, receptor affinity, and biological potency.
• Cell Culture & In Vitro Models: Applied in cell-based assays to stimulate osteoblast activity or study the effects of PTH on target tissues under controlled experimental conditions.

Basic Information

Product Name	Parathyroid Hormone (42-55), 55-Tyr- CAS NO 97613-65-5
CAS No.	97613-65-5
Molecular Formula	C78H122N22O22
Molecular Weight	1728.0 g/mol
Synonyms	PTH (42-55), 55-Tyr-; Parathyroid Hormone Fragment 42-55, 55-Tyr-; H-Tyr-Val-Ala-Leu-Gly-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH (42-55 fragment with Tyr at 55); [Tyr55]-PTH (42-55); Parathyroid Hormone (Human 42-55) (Tyr55); PTH-related peptide fragment; PTHrP (42-55) analog
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (42-55), 55-Tyr- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.