Description

Argipressin, (4-Azido)Phe(3)- is a synthetic, azido-functionalized analog of the neurohypophysial hormone arginine vasopressin. This modified peptide is a critical research tool for photoaffinity labeling and cross-linking studies, enabling the investigation of vasopressin receptor structure and function. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotech companies focused on endocrinology, neurobiology, and drug discovery for metabolic and cardiovascular disorders.

Application

• Photoaffinity Labeling Probe: Acts as a high-specificity probe for mapping the binding sites of vasopressin receptors (V1a, V1b, V2) in biochemical research.
• Receptor Cross-linking Studies: Used to covalently link and isolate receptor-ligand complexes for structural and functional analysis.
• Bioconjugation & Chemical Biology: Serves as a versatile intermediate for synthesizing advanced bioconjugates due to its reactive azido group, compatible with click chemistry.
• Mechanism of Action Research: Facilitates studies on the signaling pathways and downstream effects mediated by vasopressin receptor activation.
• Drug Discovery & Development: Employed in the design and screening of novel therapeutic candidates targeting vasopressin-related conditions like diabetes insipidus, hypertension, and stress disorders.
• Biomarker Development: Potential use in developing diagnostic assays for disorders linked to vasopressin dysregulation.

Basic Information

Product Name	Argipressin, (4-Azido)Phe(3)-
CAS No.	97474-07-2
Molecular Formula	C46H65N15O12S2
Molecular Weight	1084.2 g/mol
Synonyms	[4-Azido-Phe3]-Argipressin; [4-Azido-Phenylalanine3]-Vasopressin; 4-Azido-Phe3-AVP; 1-(3-Mercaptopropanoic acid)-2-(O-methyl-L-tyrosine)-4-azido-L-phenylalanine-8-L-arginine-vasopressin; (4-Azido)Phe(3)-Argipressin; Photoactivatable Vasopressin Analog; Azido-AVP; AVP Azido Derivative
EINECS	Contact for details

Quality Control

Our Argipressin, (4-Azido)Phe(3)- is manufactured under strict quality systems suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research specifications. For custom purity grades or specific impurity profiles, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.