Description

Gly-Arg-Gly-Asp is a synthetic tetrapeptide sequence that mimics a key cell adhesion motif found in extracellular matrix proteins. This compound is of significant value in biomedical research and development due to its ability to specifically inhibit integrin-mediated cell attachment and signaling. It is primarily needed by researchers and manufacturers in the fields of cell biology, drug discovery, and biomaterials engineering for applications ranging from fundamental studies of cell migration to the development of anti-thrombotic and anti-cancer therapeutics.

Application

• Cell Adhesion & Migration Studies: Used as a competitive inhibitor to block integrin receptors (e.g., αvβ3, αvβ5, αIIbβ3) in in vitro assays to study cell attachment, spreading, and motility.
• Biomaterial & Tissue Engineering: Incorporated into hydrogel scaffolds or surface coatings to create bioactive or non-adhesive surfaces that control cell behavior.
• Angiogenesis Research: Applied in studies investigating tumor angiogenesis and endothelial cell biology by disrupting integrin-mediated signaling pathways.
• Drug Discovery Screening: Serves as a reference standard or positive control in high-throughput screens for novel anti-integrin or anti-thrombotic drug candidates.
• Platelet Aggregation Inhibition: Used in research to study and inhibit platelet aggregation by blocking the fibrinogen receptor GPIIb/IIIa (αIIbβ3 integrin).
• Cancer Metastasis Research: Employed to investigate the role of integrins in tumor cell invasion and metastasis.
• Neuroscience Research: Utilized in studies of neuronal cell adhesion, axon guidance, and synaptic plasticity mediated by integrins.
• Peptide Synthesis & Conjugation: Acts as a building block for the synthesis of larger, more complex peptides or for conjugation to carriers, fluorophores, or nanoparticles.

Basic Information

Product Name	Gly-Arg-Gly-Asp
CAS No.	97461-81-9
Molecular Formula	C16H28N8O7
Molecular Weight	444.45 g/mol
Synonyms	GRGD; GRGD Peptide; Gly-Arg-Gly-Asp-OH; H-Gly-Arg-Gly-Asp-OH; Arg-Gly-Asp (RGD) Peptide; RGD Sequence Peptide; Adhesion Motif Peptide; Fibronectin Fragment (50-52); Integrin Binding Peptide; Cyclo(-RGDfK) precursor (linear)
EINECS	Contact for details

Quality Control

Our Gly-Arg-Gly-Asp is produced under stringent conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Composition	Conforms
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.