Description

Glutathione-Diethyl Ester (Reduced) CAS NO 97451-40-6 is a cell-permeable, lipophilic derivative of the essential antioxidant glutathione, designed to enhance intracellular delivery and stability. This compound is critical for research and development in areas requiring the modulation of cellular redox states and protection against oxidative stress. It is primarily utilized by researchers and formulators in the pharmaceutical, nutraceutical, and advanced cosmetic industries for its superior bioavailability compared to native glutathione.

Application

• Biochemical Research: Used as a tool compound to study intracellular glutathione metabolism, redox signaling pathways, and oxidative stress mechanisms in cell culture models.
• Pharmaceutical Development: Investigated as a potential active pharmaceutical ingredient (API) or intermediate in formulations targeting neurodegenerative diseases, liver disorders, and conditions linked to mitochondrial dysfunction.
• Nutraceutical & Cosmetic Actives: Incorporated into advanced dietary supplements and high-performance skincare serums for its enhanced cellular antioxidant and anti-aging properties.
• Cell Culture & Media Supplement: Acts as a protective agent in sensitive cell cultures to mitigate oxidative damage and improve cell viability under experimental stress.
• Preclinical Studies: Employed in animal models to evaluate the efficacy of glutathione replenishment therapies and their impact on various disease states.

Basic Information

Product Name	Glutathione-Diethyl Ester (Reduced)
CAS No.	97451-40-6
Molecular Formula	C14H25N3O6S
Molecular Weight	363.43 g/mol
Synonyms	L-Glutathione Diethyl Ester (Reduced); GSH Diethyl Ester; γ-Glu-Cys-Gly Diethyl Ester; Reduced Glutathione Diethyl Ester; NSC 113001; Glutathione Diethyl Ester; S-(Carboxymethyl)-L-cysteinylglycine Diethyl Ester; L-γ-Glutamyl-L-cysteinylglycine Diethyl Ester
EINECS	Contact for details

Quality Control

Our Glutathione-Diethyl Ester (Reduced) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. The material is hygroscopic and must be handled in a dry environment to minimize moisture absorption. For long-term stability, keep the container sealed and allow it to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Optical Rotation	[α]20/D: Specific range provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.