Description

Poly(Leucyl-Leucyl-Phenylalanyl-Proline) is a synthetic tetrapeptide polymer with the repeating sequence Leu-Leu-Phe-Pro. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a model substrate for studying protease activity, particularly for enzymes like prolyl oligopeptidase. It serves as a critical tool for investigating peptide degradation pathways, enzyme kinetics, and inhibitor screening. This high-purity material is essential for researchers and developers in pharmaceutical R&D, proteomics, and academic biochemistry laboratories.

Application

• Protease/Enzyme Substrate: Used as a specific model substrate for studying the activity and inhibition of prolyl oligopeptidase and related serine proteases.
• Biochemical Research: Employed in fundamental research on peptide bond cleavage, enzyme kinetics, and metabolic pathways of oligopeptides.
• Pharmaceutical Development: Serves as a key reagent in the screening and development of novel protease inhibitors for therapeutic applications.
• Diagnostic Assay Development: Utilized in the design and calibration of enzymatic assays to measure protease activity in biological samples.
• Proteomics & Peptidomics: Acts as a reference standard or a controlled degradation product in mass spectrometry and chromatography studies.
• Academic & Contract Research: Essential for university laboratories and CROs (Contract Research Organizations) conducting specialized enzymology studies.

Basic Information

Product Name	Poly(Leucyl-Leucyl-Phenylalanyl-Proline)
CAS No.	97397-92-7
Molecular Formula	(C27H40N4O5)n
Molecular Weight	~500.64 (monomer) / Polymer MW varies
Synonyms	Poly(Leu-Leu-Phe-Pro); Poly(L-Leucyl-L-leucyl-L-phenylalanyl-L-proline); (Leu-Leu-Phe-Pro)n Polymer; LLFP Polymer; Poly(LLFP); Prolyl Oligopeptidase Substrate Polymer; POP Substrate Polymer; Tetrapeptide Polymer (Leu-Leu-Phe-Pro)
EINECS	Contact for details

Quality Control

Our Poly(Leucyl-Leucyl-Phenylalanyl-Proline) is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and MS for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, molecular weight distribution, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by weight)
Amino Acid Composition	Conforms to theoretical ratio (Leu, Phe, Pro)
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.