Description

N(Alpha)-(Bis(4-Nitrophenoxy)Phosphoryl)Alanylproline is a specialized synthetic peptide derivative containing a phosphoryl group and nitrophenoxy moieties. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a key intermediate or building block for novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of enzyme inhibitors and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex peptide-based drugs and prodrugs.
• Protease Inhibitor Research: Used in the development and study of inhibitors for specific proteolytic enzymes due to its alanylproline core and phosphoryl group.
• Bioconjugation & Prodrug Design: The reactive nitrophenoxy and phosphoryl groups make it valuable for creating targeted conjugates and designing prodrugs with controlled release properties.
• Chemical Biology Probes: Employed in the creation of activity-based probes for studying enzyme function and mechanism in biological systems.
• Academic & Industrial R&D: A key reagent for synthetic organic chemists and medicinal chemists in both university laboratories and corporate R&D departments.

Basic Information

Product Name	N(Alpha)-(Bis(4-Nitrophenoxy)Phosphoryl)Alanylproline
CAS No.	97280-42-7
Molecular Formula	C20H21N4O9P
Molecular Weight	492.38 g/mol
Synonyms	N(α)-(Bis(4-Nitrophenoxy)Phosphoryl)-L-Alanyl-L-proline; Alanylproline, N-[bis(4-nitrophenoxy)phosphinyl]-; L-Alanyl-L-proline, N-[bis(p-nitrophenoxy)phosphinyl]-; N-[Bis(4-nitrophenoxy)phosphinyl]alanylproline; Phosphinylalanylproline nitrophenoxy derivative; 97280-42-7; (S)-2-((S)-1-((Bis(4-nitrophenoxy)phosphoryl)amino)-1-oxopropan-2-yl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of N(Alpha)-(Bis(4-Nitrophenoxy)Phosphoryl)Alanylproline adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.