Description

2,4-Dichloro-5-Iodo-6-Methylpyrimidine is a high-purity halogenated pyrimidine building block of significant importance in advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the selective introduction of functional groups at specific positions on the pyrimidine ring. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other heterocyclic drug candidates.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical studies.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for palladium-catalyzed Suzuki, Stille, and Sonogashira couplings.
• Nucleophilic Substitution: The chlorines are reactive sites for displacement with various nucleophiles like amines and alkoxides to create diverse pyrimidine libraries.

Basic Information

Product Name	2,4-Dichloro-5-Iodo-6-Methylpyrimidine
CAS No.	96949-46-1
Molecular Formula	C5H3Cl2IN2
Molecular Weight	288.90 g/mol
Synonyms	5-Iodo-2,4-dichloro-6-methylpyrimidine; 6-Methyl-2,4-dichloro-5-iodopyrimidine; 2,4-Dichloro-6-methyl-5-iodopyrimidine; 5-Iodo-6-methyl-2,4-dichloropyrimidine; Pyrimidine, 2,4-dichloro-5-iodo-6-methyl-; 96949-46-1; 2,4-Dichloro-5-iodo-6-methyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5-Iodo-6-Methylpyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.