Description

Cisatracurium Besylate CAS NO 96946-42-8 is a non-depolarizing neuromuscular blocking agent of the benzylisoquinolinium class, supplied as the besylate salt. It is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) valued for its predictable pharmacokinetics and cardiovascular stability profile. This compound is essential for manufacturers in the pharmaceutical industry developing neuromuscular blocking agents for use in surgical anesthesia and intensive care.

Application

• Pharmaceutical API: Primary use as the active pharmaceutical ingredient in injectable formulations for neuromuscular blockade.
• Surgical Anesthesia: A key component in anesthetic regimens to provide skeletal muscle relaxation during surgical procedures.
• Intensive Care Medicine: Used to facilitate mechanical ventilation in critically ill patients.
• Research & Development: Serves as a reference standard and starting material in pharmacological research and new drug development.
• Generic Drug Manufacturing: Critical for the production of generic versions of neuromuscular blocking agents.
• Hospital Pharmacy Compounding: Used in specialized sterile compounding within hospital settings (where regulations permit).

Basic Information

Product Name	Cisatracurium Besylate
CAS No.	96946-42-8
Molecular Formula	C65H82N2O18S2
Molecular Weight	1243.5 g/mol
Synonyms	51W89; (1R,1'R,2R,2'R)-2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium] dibenzenesulfonate; Nimbex (Brand Name); cis-Atracurium Besylate; (1R,2R)-Atracurium Besylate; 2,2'-(Pentane-1,5-diyl)bis(oxy-3-oxopropane-3,1-diyl)bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) dibenzenesulfonate
EINECS	Contact for details

Quality Control

Our Cisatracurium Besylate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and assay, identification by IR and NMR, and stringent control of related substances and residual solvents to ensure compliance with ICH guidelines and relevant pharmacopeial standards (e.g., USP, EP). A comprehensive Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C) or as specified on the label. The product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.