Description

1R, 1’R-Cis,cis-Mivacurium Chloride is a high-purity, non-depolarizing neuromuscular blocking agent of the benzylisoquinolinium class. This compound is critical for providing controlled muscle relaxation during surgical procedures and intensive care. It is primarily required by pharmaceutical manufacturers and research institutions developing anesthetic and neuromuscular blocking agents.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of injectable neuromuscular blocking agents.
• Pharmacological research and development of new anesthetic protocols.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical studies investigating the mechanism of action at the neuromuscular junction.
• Pre-clinical and clinical studies evaluating the pharmacokinetics and pharmacodynamics of muscle relaxants.

Basic Information

Product Name	1R, 1’R-Cis,cis-Mivacurium Chloride
CAS No.	107740-65-8
Molecular Formula	C58H80Cl2N2O62+ • 2Cl-
Molecular Weight	1089.10 g/mol (as dichloride salt)
Synonyms	Mivacurium Chloride (1R,1'R-cis,cis-isomer); (1R,1'R,2R,2'R)-2,2'-(3,11-Dioxo-4,10-dioxatridecamethylene)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium) Dichloride; BW B1090U; MiVacron; (1R-cis,1'R-cis)-Mivacurium Dichloride; cis-cis Mivacurium Chloride
EINECS	Contact for details

Quality Control

Our 1R, 1’R-Cis,cis-Mivacurium Chloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity, chiral analysis for isomeric content, and residual solvent analysis to ensure compliance with ICH guidelines and customer-specific requirements. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Isomeric Purity (Chiral HPLC)	≥99.0% (1R,1'R-cis,cis isomer)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Bacterial Endotoxins	<0.5 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.