Description

Dantrolene Sodium Salt is a hydantoin derivative and a direct-acting skeletal muscle relaxant that works by inhibiting calcium release from the sarcoplasmic reticulum. This mechanism makes it a critical pharmaceutical active ingredient for managing conditions associated with hypermetabolic skeletal muscle activity. It is essential for manufacturers in the pharmaceutical and life science research sectors requiring a high-purity, reliable compound for therapeutic formulation and biochemical studies.

Application

• Pharmaceutical Manufacturing: Primary use as the active pharmaceutical ingredient (API) in oral and injectable formulations for the treatment of malignant hyperthermia.
• Muscle Spasticity Management: Used in the production of medications for chronic conditions such as muscle spasticity associated with spinal cord injury, stroke, cerebral palsy, or multiple sclerosis.
• Hospital Emergency Use: A vital component in emergency kits and injectable solutions prepared for acute malignant hyperthermia crises during anesthesia.
• Biomedical Research: Serves as a key pharmacological tool in preclinical studies investigating calcium signaling, muscle physiology, and neuromuscular disorders.
• Reference Standard: Utilized as a high-purity chemical reference standard in quality control laboratories for analytical method development and validation.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for the management of malignant hyperthermia in susceptible animal breeds.

Basic Information

Product Name	Dantrolene Sodium Salt
CAS No.	14663-23-1
Molecular Formula	C14H9N4NaO5
Molecular Weight	336.24 g/mol
Synonyms	Dantrolene Sodium; Dantrium; Dantrolene Sodium Hydrate; 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione Sodium Salt; Sodium 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]hydantoin; F-368; Dantrolene Na Salt; Dantrolene Sodium Salt Hydrate
EINECS	238-703-5

Quality Control

Our Dantrolene Sodium Salt is manufactured under strict quality systems. It is typically produced to meet in-house specifications aligned with pharmaceutical-grade requirements, ensuring high purity and consistency for critical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.