Description

Baclofen CAS NO 1134-47-0 is a high-purity pharmaceutical active ingredient, specifically a γ-aminobutyric acid (GABA) derivative. It serves as a critical muscle relaxant and antispastic agent, essential for managing conditions involving muscle spasticity. This compound is primarily required by pharmaceutical manufacturers and research institutions for the formulation of central nervous system (CNS) medications and advanced neurological studies.

Application

• Pharmaceutical Manufacturing: Primary active ingredient in oral tablets and intrathecal solutions for treating muscle spasticity associated with multiple sclerosis, spinal cord injuries, and cerebral palsy.
• Neurological Research: Used as a selective GABAB receptor agonist in preclinical studies to investigate neurotransmission, spasticity mechanisms, and potential new therapeutic pathways.
• Reference Standard: Serves as a certified reference material (CRM) for quality control testing, method validation, and regulatory submissions in analytical laboratories.
• Chemical Synthesis: Acts as a key intermediate or starting material for the synthesis of more complex pharmaceutical compounds and novel analogs.

Basic Information

Product Name	Baclofen
CAS No.	1134-47-0
Molecular Formula	C10H12ClNO2
Molecular Weight	213.66 g/mol
Synonyms	β-(Aminomethyl)-4-chlorobenzenepropanoic Acid; 4-Amino-3-(4-chlorophenyl)butyric Acid; Lioresal; Gablofen; Kemstro; Baclopar; Baclosan; β-(4-Chlorophenyl)-GABA
EINECS	214-486-9

Quality Control

Our Baclofen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability and compliance for your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.