Description

Doxacurium Chloride is a long-acting, non-depolarizing neuromuscular blocking agent belonging to the benzylisoquinolinium class. Its primary value lies in providing sustained skeletal muscle relaxation during prolonged surgical procedures, offering anesthesiologists precise control. This compound is essential for pharmaceutical manufacturers developing injectable anesthetic formulations and for research institutions studying neuromuscular pharmacology. Doxacurium Chloride CAS NO 106819-53-8 is a critical intermediate in the synthesis of advanced pharmaceutical actives.

Application

• Primary active pharmaceutical ingredient (API) in the formulation of long-acting neuromuscular blocking agents for surgical anesthesia.
• Key intermediate in the research and development of new benzylisoquinolinium-based muscle relaxants.
• Reference standard in analytical laboratories for quality control and method development (HPLC, LC-MS).
• Pharmacological research tool for in vitro and in vivo studies of nicotinic acetylcholine receptors at the neuromuscular junction.
• Used in preclinical and clinical studies to investigate the kinetics and dynamics of non-depolarizing neuromuscular blockade.
• Critical material for compounding pharmacies and hospital pharmacies preparing specialized anesthetic kits (where regulatory approved).

Basic Information

Product Name	Doxacurium Chloride
CAS No.	106819-53-8
Molecular Formula	C56H78Cl2N2O182+ • 2Cl-
Molecular Weight	1106.98 g/mol (for the dichloride salt)
Synonyms	BW A938U; Doxacurium Dichloride; (1R,1'R,2S,2'S)-2,2'-[1,8-Dioxo-4,9-dioxa-1,8-dodecanediylbis(oxy)]bis[N,N,N-trimethyl-1,2,3,4-tetrahydro-6,7,8-trimethoxy-2-methyl-1-isoquinolinaminium] Dichloride; Nuromax; BW-A938U; BWA 938U
EINECS	Contact for details

Quality Control

Our Doxacurium Chloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results against relevant specifications is provided with every shipment. We support compliance with cGMP, ICH Q7, and other major pharmacopeial guidelines for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details
Bacterial Endotoxins	< 0.5 EU/mg (for injectable grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.