Description

Calcitonin Gene Related Peptide Rat is a synthetic peptide fragment corresponding to the rat-specific sequence of the Calcitonin Gene-Related Peptide (CGRP), a potent neuropeptide with significant biological activity. This high-purity reference standard is essential for advancing neurological and cardiovascular research, providing a critical tool for studying pain pathways, migraine mechanisms, and vascular biology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) engaged in preclinical studies and assay development.

Application

• Neuroscience Research: Used as a reference standard in studies investigating the role of CGRP in pain transmission, migraine pathophysiology, and neurogenic inflammation.
• Cardiovascular Studies: Employed in research models to examine CGRP's vasodilatory effects and its function in regulating blood pressure and local blood flow.
• Assay Development & Validation: Serves as a critical calibrant and positive control in the development of immunoassays (ELISA, RIA) and receptor binding assays targeting the CGRP pathway.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel CGRP receptor antagonists and therapeutic candidates.
• Academic & Preclinical Research: Provides a reliable tool for in vitro and in vivo studies exploring CGRP signaling in various disease models.
• Quality Control Reference: Acts as an analytical standard for the purity and potency assessment of related peptide-based pharmaceuticals and research reagents.

Basic Information

Product Name	Calcitonin Gene Related Peptide Rat
CAS No.	96827-03-1
Molecular Formula	C164H263N51O53S2
Molecular Weight	3793.3 g/mol
Synonyms	Rat CGRP; CGRP (rat); Calcitonin Gene-Related Peptide, rat; α-CGRP (rat); CGRP-I (rat); CGRP Fragment; Neuropeptide; H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7)
EINECS	Contact for details

Quality Control

Our Calcitonin Gene Related Peptide Rat is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) documenting purity, peptide content, and solvent residues is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.