Description

Norketamine Hydrochloride is a high-purity pharmaceutical intermediate and analytical reference standard. This compound is critical for research and development in neuropharmacology and forensic chemistry, serving as a key metabolite of ketamine. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for method development, quality control, and metabolic studies. Our product ensures reliable performance and consistent quality for your most demanding applications.

Application

• Pharmaceutical Intermediate: Used in the synthesis and research of novel central nervous system (CNS) active compounds and their metabolites.
• Analytical Reference Standard: Serves as a certified standard for quantitative and qualitative analysis in forensic toxicology and clinical research.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism of ketamine and related arylcyclohexylamines.
• Biomedical Research: Employed in in-vitro and in-vivo studies investigating NMDA receptor antagonism and neuropharmacological mechanisms.
• Quality Control: Used by pharmaceutical companies to develop and validate analytical methods for impurity profiling and assay determination.
• Regulatory Compliance: Supports compliance testing and documentation for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Norketamine Hydrochloride
CAS No.	96783-51-6
Molecular Formula	C12H15Cl2NO
Molecular Weight	260.16 g/mol
Synonyms	Desmethylketamine Hydrochloride; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride; Nor-Ketamine HCl; Norketamine HCl; (±)-Norketamine Hydrochloride; Ketamine Metabolite Hydrochloride; CL-88 Hydrochloride
EINECS	Contact for details

Quality Control

Our Norketamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and related substances. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications developed for research and pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.