Description

β-Endorphin, Tyr(18), Trp(27)- CAS NO 96684-84-3 is a synthetic, modified peptide analog of the endogenous neuropeptide β-endorphin, designed for enhanced stability and specific receptor interaction. This compound is of significant value for advanced research in neurobiology, pain management, and psychopharmacology due to its targeted activity. It is primarily required by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in developing novel therapeutics for central nervous system disorders and analgesia.

Application

• Neuroscientific Research: Used as a high-purity reference standard and tool compound for studying opioid receptor signaling pathways, neurotransmitter release, and neuroplasticity.
• Analgesic Drug Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in preclinical studies for developing next-generation, non-addictive pain relievers.
• Psychiatric Disorder Models: Applied in research models investigating the role of the endorphin system in stress, depression, anxiety, and reward mechanisms.
• Biochemical Assays: Utilized in receptor binding assays, cell-based functional tests, and in vitro pharmacological profiling to determine potency and selectivity.
• Metabolic Studies: Employed to investigate peptide stability, metabolism, and blood-brain barrier penetration in pharmacokinetic research.

Basic Information

Product Name	β-Endorphin, Tyr(18), Trp(27)- CAS NO 96684-84-3
CAS No.	96684-84-3
Molecular Formula	C158H239N41O46S
Molecular Weight	3466.9 g/mol
Synonyms	β-Endorphin (Tyr18, Trp27); [Tyr18,Trp27]-β-Endorphin; β-Endorphin (18-31), Tyr(18), Trp(27)-; Modified β-Endorphin Fragment; H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH (with Tyr18, Trp27 substitutions); Opioid Peptide Analog; Research Peptide 96684-84-3
EINECS	Contact for details

Quality Control

Our β-Endorphin, Tyr(18), Trp(27)- CAS NO 96684-84-3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis to meet specific purity requirements (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.