Description

H-Pro-Amc . HBr is a high-purity, protected amino acid derivative, specifically the hydrobromide salt of the Fmoc-protected proline amide. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains with proline residues. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated or manual synthesis of custom peptides.
• Pharmaceutical R&D: For the research and development of novel peptide-based drugs, hormones, and vaccines.
• Bioconjugation: Used in the preparation of peptide-protein conjugates or peptide-labeled compounds for targeted therapies.
• Combinatorial Chemistry: Serves as a fundamental monomer in libraries for high-throughput screening of bioactive compounds.
• Academic Research: A standard reagent in university and institutional labs studying protein structure, function, and peptide interactions.
• Process Development: For scaling up the production of specific peptide sequences in a GMP or non-GMP environment.

Basic Information

Product Name	H-Pro-Amc . HBr
CAS No.	96643-94-6
Molecular Formula	C21H22BrN3O3
Molecular Weight	444.33 g/mol
Synonyms	Fmoc-Pro-NH2 . HBr; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolinamide hydrobromide; Fmoc-L-prolinamide hydrobromide; Fmoc-Pro-NH2 . HBr; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-N-carbamoylpyrrolidine-1-ium bromide; Fmoc-Proline amide HBr salt; Nα-Fmoc-L-prolinamide hydrobromide; Fmoc-Pro-Amide . HBr
EINECS	Contact for details

Quality Control

Every batch of H-Pro-Amc . HBr is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive peptide synthesis applications. A Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), chiral purity, and identity is supplied with each shipment. Our quality protocols are designed to support compliance in research and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.