Description

Ricin, A Chain CAS NO 96638-28-7 is a highly potent protein toxin derived from the castor bean plant, specifically the cytotoxic polypeptide chain of the ricin toxin. This compound is of significant interest in biomedical research due to its specific mechanism of action, which involves the inhibition of protein synthesis in eukaryotic cells. It is primarily utilized by research institutions and pharmaceutical developers focusing on targeted cancer therapies, immunotoxin development, and fundamental studies in cell biology and toxicology.

Application

• Biomedical Research: Used as a tool to study ribosomal inactivation, apoptosis, and intracellular trafficking mechanisms.
• Immunotoxin Development: Serves as the cytotoxic payload in antibody-drug conjugates (ADCs) and other targeted therapeutic constructs for oncology research.
• Cancer Research: Investigated for its potential in targeted cancer therapy due to its extreme cytotoxicity when delivered specifically to tumor cells.
• Vaccine Research: Employed in the development of prophylactic vaccines against ricin intoxication.
• Diagnostic Reagent Production: Used in the manufacture of control materials and calibrators for ricin detection assays and forensic analysis.
• Cell Biology Studies: Applied in experiments to selectively ablate specific cell populations or study protein synthesis pathways.

Basic Information

Product Name	Ricin, A Chain
CAS No.	96638-28-7
Molecular Formula	C~1800~H~2800~N~480~O~540~S~10~ (Approximate for protein)
Molecular Weight	~32 kDa
Synonyms	Ricin Toxin A Chain; Ricin A-Chain; RCA; Ricinus communis Agglutinin A Chain; RT-A; N-Glycosidase; RIP (Ribosome-Inactivating Protein) Type 2 A Chain; Toxin RCA A Chain
EINECS	Contact for details

Quality Control

Our Ricin A Chain is produced and handled under stringent conditions to ensure research-grade quality and batch-to-batch consistency. Each lot undergoes comprehensive analysis including purity assessment by SDS-PAGE and HPLC, activity testing, and endotoxin level checks. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and biological activity specifications. Production adheres to relevant biosafety and quality guidelines for research biochemicals.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent degradation. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Corresponds to standard
Purity (HPLC)	≥ 95%
Protein Content	≥ 90% (Biuret)
Biological Activity (Cell-free assay)	Contact for details
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in PBS or suitable aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.