Description

S-(1,2-Dichlorovinyl)Glutathione is a specific glutathione conjugate formed via the mercapturic acid pathway, primarily as a metabolite of trichloroethylene and related chlorinated solvents. This compound is of significant value in biochemical and toxicological research for studying the metabolic activation and detoxification pathways of environmental contaminants. It serves as a critical reference standard and research reagent for scientists in analytical chemistry, environmental toxicology, and mechanistic pharmacology.

Application

• Biomarker Research: Used as a reference standard for identifying and quantifying glutathione-derived metabolites in biological samples to assess exposure to chlorinated ethenes.
• Toxicological Studies: Essential for investigating the nephrotoxic and carcinogenic mechanisms associated with trichloroethylene metabolism.
• Analytical Method Development: Serves as a high-purity calibrant in LC-MS/MS and HPLC methods for metabolic profiling.
• Enzymology Research: Utilized in studies of glutathione S-transferase (GST) activity and specificity towards halogenated alkenes.
• Reference Material: Provides a certified standard for quality control in laboratories conducting environmental or occupational health monitoring.

Basic Information

Product Name	S-(1,2-Dichlorovinyl)Glutathione
CAS No.	96614-59-4
Molecular Formula	C12H18Cl2N3O6S
Molecular Weight	403.26 g/mol
Synonyms	S-(1,2-Dichloroethenyl)glutathione; 1,2-Dichlorovinyl Glutathione; DCVG; Glutathione S-(1,2-dichlorovinyl) ester; L-γ-Glutamyl-S-(1,2-dichlorovinyl)-L-cysteinylglycine; NSC 339588; S-(trans-1,2-Dichlorovinyl)glutathione
EINECS	Contact for details

Quality Control

Our S-(1,2-Dichlorovinyl)Glutathione is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under nitrogen or argon and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.