Description

Boc-D-Lys(Tfa)-Oh is a protected derivative of the D-isomer of the amino acid lysine, featuring tert-butoxycarbonyl (Boc) and trifluoroacetyl (Tfa) protecting groups. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry and side-chain functionality. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers for the development of therapeutic peptides, diagnostic agents, and advanced biomaterials.

Application

• Pharmaceutical Intermediates: Key chiral synthon in the solid-phase and solution-phase synthesis of therapeutic peptides and peptide-based drugs.
• Bioconjugation: Used to introduce modified lysine residues into proteins and antibodies for drug-linker conjugation in ADC (Antibody-Drug Conjugate) development.
• Proteomics Research: Serves as a standard or building block for creating isotopically labeled peptides for mass spectrometry-based quantitative proteomics.
• Biomaterial Engineering: Incorporation into custom peptide sequences designed for hydrogels, tissue engineering scaffolds, and bioactive coatings.
• Chemical Biology Probes: Synthesis of activity-based probes and affinity tags to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in the asymmetric synthesis of non-proteinogenic amino acids and complex natural products.

Basic Information

Product Name	Boc-D-Lys(Tfa)-Oh
CAS No.	96561-04-5
Molecular Formula	C₁₃H₂₁F₃N₂O₅
Molecular Weight	342.31 g/mol
Synonyms	Nα-Boc-Nε-trifluoroacetyl-D-lysine; D-Lysine, N2-[(1,1-dimethylethoxy)carbonyl]-N6-(trifluoroacetyl)-; Boc-D-Lys(TFA)-OH; N-Boc-N'-Tfa-D-lysine; tert-Butyloxycarbonyl-Nε-trifluoroacetyl-D-lysine; (S)-2-((tert-Butoxycarbonyl)amino)-6-(2,2,2-trifluoroacetamido)hexanoic acid; Boc-D-Lys(Tfa)-OH CAS 96561-04-5
EINECS	Contact for details

Quality Control

Our Boc-D-Lys(Tfa)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.