Description

Methoxycarbonyl-Lys(Z)-Gly-Arg-Pna is a specialized synthetic peptide derivative, specifically a chromogenic substrate designed for enzymatic activity studies. This compound is critical for biochemical research and pharmaceutical development, enabling precise measurement of protease activity. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in enzyme kinetics, inhibitor screening, and assay development.

Application

• Protease Activity Assays: As a chromogenic p-nitroanilide (Pna) substrate for the quantitative determination of trypsin, thrombin, and related serine protease activities.
• Biochemical Research: A key tool in enzymology for studying enzyme kinetics, specificity, and inhibition mechanisms in vitro.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors for drug discovery.
• Diagnostic Development: Employed in the formulation of diagnostic kits for clinical measurements of coagulation factors and other protease-related biomarkers.
• Quality Control: Serves as a reference standard in the quality control of therapeutic enzymes and biopharmaceutical products.

Basic Information

Product Name	Methoxycarbonyl-Lys(Z)-Gly-Arg-Pna
CAS No.	96559-87-4
Molecular Formula	C33H46N8O9
Molecular Weight	698.77 g/mol
Synonyms	MOC-Lys(Z)-Gly-Arg-pNA; Methoxycarbonyl-Nε-carbobenzoxy-L-lysylglycyl-L-arginine 4-nitroanilide; Chromogenic Substrate for Trypsin; Boc-Lys(Z)-Gly-Arg-pNA (common misnomer); Z-Lys-Gly-Arg-pNA derivative; Protease Substrate 96559-87-4; Nα-Methoxycarbonyl-Nε-carbobenzyloxy-L-lysylglycyl-L-arginine 4-nitroanilide acetate salt
EINECS	Contact for details

Quality Control

Our Methoxycarbonyl-Lys(Z)-Gly-Arg-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.