Description

5-Trifluoromethyl-Thiophene-3-Carbaldehyde is a high-purity fluorinated heterocyclic building block, essential for advanced organic synthesis. This compound is valued for its unique trifluoromethyl-substituted thiophene scaffold, which imparts desirable electronic and metabolic properties to target molecules. It is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for conjugated polymers, organic semiconductors, and non-linear optical (NLO) materials due to its electron-withdrawing characteristics.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and introducing fluorine atoms into complex molecular architectures.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific fine chemicals and advanced intermediates.

Basic Information

Product Name	5-Trifluoromethyl-Thiophene-3-Carbaldehyde
CAS No.	96518-84-2
Molecular Formula	C6H3F3OS
Molecular Weight	180.15 g/mol
Synonyms	3-Formyl-5-(trifluoromethyl)thiophene; 5-(Trifluoromethyl)thiophene-3-carboxaldehyde; Thiophene-3-carboxaldehyde, 5-(trifluoromethyl)-; 5-Trifluoromethyl-3-thiophenecarboxaldehyde; 3-Thiophenecarboxaldehyde, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-Thiophene-3-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.