Description

(S)-n-Fmoc-1-Naphthylalanine is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block in the development of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the synthesis of bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled assembly of complex peptide sequences.
• Peptidomimetic Drug Discovery: Incorporation of the bulky, hydrophobic 1-naphthyl side chain to modulate peptide conformation, stability, and receptor binding affinity.
• Medicinal Chemistry & Lead Optimization: Used to introduce structural diversity and explore structure-activity relationships (SAR) in novel therapeutic candidates.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescent or affinity-labeled peptides for biochemical assays and diagnostic tools.
• Academic and Industrial Research: Essential reagent for synthesizing model peptides to study protein folding, interactions, and enzyme mechanisms.

Basic Information

Product Name	(S)-n-Fmoc-1-Naphthylalanine
CAS No.	96402-49-2
Molecular Formula	C28H23NO4
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-1-Nal-OH; Fmoc-Nal(1)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-naphthyl-L-alanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-1-yl)propanoic acid; Fmoc-L-1-Naphthylalanine; Fmoc-α-Me-1-Naphthylalanine (related); Nα-Fmoc-1-naphthylalanine
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-1-Naphthylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable to support pre-clinical and development-phase pharmaceutical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.