Description

Lhrh, (N)-Ac-3(2-Naphthyl)Ala(1)-(4-Cl-Phe)(2)-Trp(3)-Arg(6)-Phe(7)-Alanh2(10)- is a synthetic decapeptide analog of Luteinizing Hormone-Releasing Hormone (LHRH), featuring specific amino acid substitutions to modulate its biological activity and stability. This compound is of significant interest for advanced research in endocrinology and the development of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on neuroendocrinology, oncology, and reproductive medicine.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active investigational compound in the development of novel LHRH receptor agonists or antagonists for therapeutic applications.
• Endocrinology Studies: Used in in vitro and in vivo research to study the pituitary-gonadal axis, hormone signaling pathways, and feedback mechanisms.
• Oncology Research: Investigated for its potential role in hormone-dependent cancers, such as prostate and breast cancer, due to its ability to interact with LHRH receptors often expressed on tumor cells.
• Reproductive Biology: Applied in studies concerning fertility, contraception, and disorders of the reproductive system.
• Biochemical Assay Development: Employed as a critical component in the development and validation of high-throughput screening (HTS) assays, ELISA tests, and receptor binding studies.
• Peptide Chemistry & Structure-Activity Relationship (SAR) Studies: Provides a valuable template for medicinal chemists to explore the impact of specific structural modifications (e.g., naphthylalanine, chlorophenylalanine) on peptide stability, receptor affinity, and pharmacokinetic properties.

Basic Information

Product Name	Lhrh, (N)-Ac-3(2-Naphthyl)Ala(1)-(4-Cl-Phe)(2)-Trp(3)-Arg(6)-Phe(7)-Alanh2(10)-
CAS No.	96394-82-0
Molecular Formula	C72H88ClN17O13
Molecular Weight	1411.0 g/mol (approx.)
Synonyms	Ac-D-2-Nal-4-Cl-D-Phe-D-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-D-Ala-NH2; LHRH Antagonist (Analog); [Ac-D-2-Nal1, D-4-Cl-Phe2, D-Trp3, D-Arg6, D-Ala10]-LHRH; GnRH Antagonist Analog; Gonadotropin-Releasing Hormone Antagonist Peptide; Cetrorelix-related analog; 96394-82-0; Synthetic LHRH Decapeptide.
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Lhrh, (N)-Ac-3(2-Naphthyl)Ala(1)-(4-Cl-Phe)(2)-Trp(3)-Arg(6)-Phe(7)-Alanh2(10)- undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide Certificates of Analysis (COA) detailing all relevant specifications to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	Within ±10% of theoretical values

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.