Description

D-o-Phospho Threonine is a phosphorylated derivative of the amino acid threonine, serving as a critical building block in advanced biochemical research and synthesis. This compound is essential for studying and modulating protein phosphorylation pathways, a fundamental regulatory mechanism in cellular biology. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in peptide synthesis, enzyme studies, and the development of novel therapeutics.

Application

• Phosphopeptide Synthesis: A key protected intermediate for the solid-phase or solution-phase synthesis of phosphopeptides, mimicking post-translational modifications.
• Biochemical Research: Used as a substrate or standard in kinase/phosphatase activity assays to study signal transduction pathways.
• Pharmaceutical Development: Employed in the research and development of targeted drugs that interact with phospho-dependent protein domains.
• Proteomics & Diagnostics: Serves as a reference compound in mass spectrometry for the identification and quantification of phosphorylated proteins.
• Enzyme Mechanism Studies: Utilized to investigate the specificity and catalytic mechanisms of enzymes involved in phosphorylation events.
• Cell Culture & Media Supplements: Can be incorporated into specialized cell culture media for metabolic studies requiring phosphorylated amino acids.

Basic Information

Product Name	D-o-Phospho Threonine
CAS No.	96193-69-0
Molecular Formula	C₄H₁₀NO₆P
Molecular Weight	199.10 g/mol
Synonyms	D-Threonine, O-phosphono-; (2R,3S)-2-Amino-3-phosphonoxybutanoic acid; O-Phospho-D-threonine; Phosphothreonine D-isomer; D-Phosphothreonine; D-Thr(PO3H2); Fmoc-D-Thr(PO(OBzl)OH)-OH (protected form precursor); D-2-Amino-3-phosphonoxybutyric acid
EINECS	Contact for details

Quality Control

Our D-o-Phospho Threonine is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.