Description

3'-o-Benzyl-2'-Deoxy-5-Trifluoromethyluridine is a high-purity, modified nucleoside building block essential for advanced pharmaceutical research and development. This compound is specifically engineered to introduce the 5-trifluoromethyluridine moiety into oligonucleotide sequences, offering enhanced metabolic stability and binding affinity. It is a critical intermediate for medicinal chemists and researchers in the fields of antiviral drug discovery, antisense oligonucleotide (ASO) synthesis, and diagnostic probe development. Our supply ensures consistent quality and reliable availability for global R&D and pilot-scale production needs.

Application

• Antiviral Drug Intermediate: A key synthetic precursor for novel nucleoside analog therapeutics targeting viral polymerases.
• Antisense Oligonucleotide (ASO) Synthesis: Used in the solid-phase or solution-phase synthesis of modified oligonucleotides for gene silencing applications.
• Diagnostic Probe Development: Incorporation into fluorescent or radioactive probes for molecular diagnostics and bioimaging.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies to optimize drug potency and pharmacokinetics.
• Bioconjugation: The benzyl protecting group allows for selective deprotection and further functionalization in complex bioconjugate synthesis.
• Academic & Institutional Research: Fundamental research in nucleic acid chemistry, enzymology, and molecular biology.

Basic Information

Item	Detail
Product Name	3'-o-Benzyl-2'-Deoxy-5-Trifluoromethyluridine
CAS No.	96141-37-6
Molecular Formula	C17H17F3N2O5
Molecular Weight	386.32 g/mol
Synonyms	5-Trifluoromethyl-2'-deoxy-3'-O-benzyluridine; 2'-Deoxy-3'-O-benzyl-5-(trifluoromethyl)uridine; 3'-O-Benzyl-5-trifluoromethyl-2'-deoxyuridine; 3'-O-Benzyl-5-CF3-2'-deoxyuridine; 5-Trifluoromethyl-3'-O-benzyl-2'-deoxyuridine; 3'-O-Bn-5-CF3-dU; 3'-O-Benzyl-5-trifluoromethyldeoxyuridine; 3'-O-Benzyl-2'-deoxy-5-(trifluoromethyl)uridine
EINECS	Contact for details

Quality Control

Our 3'-o-Benzyl-2'-Deoxy-5-Trifluoromethyluridine is manufactured under strict quality systems to meet the exacting standards of pharmaceutical R&D. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant ICH guidelines for impurities and utilize advanced analytical techniques including HPLC, NMR, and MS for characterization. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.