Description

Corticotropin Releasing Hormone (9-41) is a potent and specific antagonist of the corticotropin-releasing hormone receptor (CRHR1). This peptide fragment is a critical research tool for studying the hypothalamic-pituitary-adrenal (HPA) axis, stress response, and related neurological pathways. It is essential for pharmaceutical R&D, academic neuroscience research, and the development of novel therapeutics targeting anxiety, depression, and metabolic disorders.

Application

• Neuroscience Research: Used as a selective CRH receptor antagonist to investigate the physiology of stress, anxiety, and depression in preclinical models.
• Endocrine Studies: A key reagent for studying the regulation of the HPA axis and adrenocorticotropic hormone (ACTH) release.
• Drug Discovery & Development: Serves as a reference standard and pharmacological tool in screening assays for novel CRHR1 antagonists.
• Behavioral Pharmacology: Employed in studies exploring the link between neuropeptides, stress-related behaviors, and learning.
• Metabolic Research: Applied in research investigating the role of CRH in appetite regulation, energy balance, and gastrointestinal function.
• Academic & Institutional Labs: A fundamental component for graduate and postdoctoral research in neuroendocrinology and psychopharmacology.

Basic Information

Product Name	Corticotropin Releasing Hormone (9-41)
CAS No.	96118-75-1
Molecular Formula	C206H342N60O63S
Molecular Weight	4676.3 g/mol
Synonyms	CRH (9-41); Corticotropin-Releasing Factor (9-41); CRF (9-41); α-Helical CRF(9-41); Astressin; CRH Antagonist (9-41); h/rCRF(9-41); Corticoliberin (9-41)
EINECS	Contact for details

Quality Control

Our Corticotropin Releasing Hormone (9-41) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solubility	Soluble in water or dilute acetic acid
Single Impurity (HPLC)	≤ 1.0%
Water Content (K.F.)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.