Description

Atrial Natriuretic Factor (4-28) (Human) is a synthetic peptide fragment corresponding to the biologically active core of the human atrial natriuretic peptide (ANP) hormone. This compound is a critical research tool for studying cardiovascular physiology, renal function, and the mechanisms of blood pressure regulation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on hypertension, heart failure, and natriuretic peptide receptor signaling pathways.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of natriuretic peptide receptors (NPR-A, NPR-C), cyclic GMP signaling, and vascular smooth muscle relaxation.
• Cardiovascular Pharmacology: Serves as a key substrate for screening and developing novel therapeutic agents targeting hypertension, congestive heart failure, and cardiac hypertrophy.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA, RIA) designed to measure ANP levels in biological samples for clinical diagnostics.
• Signal Transduction Studies: Essential for investigating the downstream biochemical pathways activated by ANP binding, including guanylyl cyclase activation and diuretic/natriuretic responses.
• Academic & Institutional Labs: A fundamental reagent for teaching and advanced research in endocrinology, renal physiology, and peptide hormone action.

Basic Information

Product Name	Atrial Natriuretic Factor (4-28) (Human)
CAS No.	95896-08-5
Molecular Formula	C128H204N42O39S2
Molecular Weight	2931.4 g/mol
Synonyms	ANF (4-28), human; Atrial Natriuretic Peptide (4-28); ANP (4-28); Atriopeptin (4-28); Cardionatrin (4-28); Auriculin A (4-28); hANP (4-28); Ser103-Tyr126 Atrial Natriuretic Factor (Human)
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Factor (4-28) (Human) is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to relevant guidelines for peptide synthesis and can provide material traceable to primary reference standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Solubility	Soluble in water or aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.