Description

Ac-(Tyr(SO3H)27)-Cholecystokinin Fragment 26-29 Amide is a chemically synthesized, sulfated peptide fragment derived from the gastrointestinal hormone cholecystokinin (CCK). This modified sequence is a critical research tool for studying CCK receptor binding, activation, and signal transduction pathways. It is essential for pharmaceutical R&D, academic research, and diagnostic development in the fields of gastroenterology, neuroscience, and metabolic disorders.

Application

• Pharmacological Research: Used as a high-affinity ligand for the detailed study and characterization of CCK receptor subtypes (CCKA and CCKB/gastrin receptors).
• Drug Discovery & Development: Serves as a reference standard and lead compound in the design of novel therapeutics targeting digestive functions, satiety, anxiety, and pain.
• Biochemical Assays: Employed in competitive binding assays (e.g., radioimmunoassays, fluorescence polarization) to screen for receptor agonists and antagonists.
• Academic & Clinical Studies: Facilitates fundamental research into the role of CCK in pancreatic secretion, gallbladder contraction, gut-brain axis communication, and behavior.
• Diagnostic Development: Acts as a key component in developing in vitro diagnostic kits for research purposes related to receptor function and hormone activity.

Basic Information

Item	Details
Product Name	Ac-(Tyr(SO3H)27)-Cholecystokinin Fragment 26-29 Amide
CAS No.	95833-37-7
Molecular Formula	C30H41N7O13S2
Molecular Weight	795.9 g/mol
Synonyms	Ac-CCK-4 (sulfated); Ac-Tyr(SO3H)-Met-Gly-Trp-Met-NH2; Cholecystokinin (26-29), N-acetyl-O-sulfotyrosyl-, amide; CCK-4 Sulfated Fragment; Ac-[Tyr(SO3H)27]CCK-26-29; Ac-CCK-4 Sulfate; CCK Tetrapeptide Sulfate Amide; N-Acetyl-O-sulfonyl-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methioninamide
EINECS	Contact for details

Quality Control

Every batch of Ac-(Tyr(SO3H)27)-Cholecystokinin Fragment 26-29 Amide is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including HPLC chromatograms and mass spectrometry data, to verify identity, purity, and peptide content. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), amino acid analysis, and mass spec confirmation are available for all commercial and research quantities.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.