Description

Fmoc-4-Amino-L-Phenylalanine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the unique 4-aminophenylalanine residue into peptide chains, enabling the creation of peptides with specific functionalization sites for bioconjugation or structural modification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for developing novel therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Research: Building block for novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation & Labeling: The aromatic amine group, after deprotection, provides a specific site for attaching fluorescent dyes, affinity tags, or other functional molecules.
• Structure-Activity Relationship (SAR) Studies: Used to incorporate modified phenylalanine analogs into peptides to study biological activity and optimize properties.
• Biotechnology & Proteomics: Synthesis of specialized peptide substrates, inhibitors, or standards for enzymatic assays and protein analysis.
• Material Science: Precursor for creating peptide-based biomaterials and hydrogels with tailored functionalities.

Basic Information

Product Name	Fmoc-4-Amino-L-Phenylalanine
CAS No.	95753-56-3
Molecular Formula	C24H22N2O4
Molecular Weight	402.45 g/mol
Synonyms	Fmoc-4-NH2-Phe-OH; Fmoc-Phe(4-NH2)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-amino-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-aminophenyl)propanoic acid; Fmoc-L-Phe(4-NH2)-OH; 4-Amino-L-phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-4-Aminophenylalanine; Fmoc-4-Amino-DL-phenylalanine (related racemic mixture)
EINECS	Contact for details

Quality Control

Our Fmoc-4-Amino-L-Phenylalanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation by spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.