Description

Charybdotoxin is a high-potency, 37-amino acid peptide neurotoxin originally isolated from the venom of the scorpion *Leiurus quinquestriatus hebraeus*. This compound is a highly selective and potent blocker of high-conductance calcium-activated potassium (BK) channels, making it an indispensable research tool in electrophysiology and neuroscience. It is primarily utilized by academic researchers, pharmaceutical R&D teams, and diagnostic developers studying ion channel function, neuronal excitability, and cardiovascular physiology.

Application

• Neuroscience Research: A critical pharmacological tool for selectively inhibiting BK channels to study their role in action potential repolarization, neurotransmitter release, and neuronal firing patterns.
• Cardiovascular Research: Used to investigate the function of BK channels in vascular smooth muscle tone regulation, blood pressure control, and cardiac electrophysiology.
• Ion Channel Screening & Drug Discovery: Employed as a reference standard and positive control in high-throughput screening assays to identify novel modulators of potassium channels for therapeutic development.
• Physiological Studies: Applied in patch-clamp and other electrophysiological experiments to dissect the contribution of BK channels to cellular excitability in various tissues, including endocrine cells and smooth muscle.
• Biochemical Research: Used in studies of toxin-channel interactions, structure-activity relationships (SAR), and the development of labeled derivatives for binding assays.

Basic Information

Product Name	Charybdotoxin
CAS No.	95751-30-7
Molecular Formula	C185H277N55O57S7
Molecular Weight	~4290.9 g/mol
Synonyms	Charybdotoxin; ChTX; CTX; Leiurotoxin I; Iberiotoxin homolog; Potassium channel blocker toxin α-KTx 1.1; Scorpion toxin ChTX
EINECS	Contact for details

Quality Control

Our Charybdotoxin is produced and purified under stringent conditions to ensure the highest standards of biological activity and purity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, bioactivity, and sterility data. We adhere to ISO 9001 quality management principles, and our processes are designed to meet the exacting requirements of the global life science research community.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -20°C to -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Bioactivity)	≥ 98% (by functional assay)
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 1.0 EU/µg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.