Description

4-Amino-5-Ethyl-1-[(2R,3S,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidin-2-One is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound is valued for its precise stereochemistry and functional groups, which make it a critical intermediate in the synthesis of novel antiviral and anticancer agents. It is primarily sought after by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology sectors for the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel nucleoside-based antiviral drugs.
• Antiviral Drug Development: Used in research targeting viruses such as hepatitis B (HBV), hepatitis C (HCV), and other RNA/DNA viruses.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic agents that target DNA/RNA synthesis in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for the custom manufacturing of specialized nucleotide derivatives for targeted therapies.

Basic Information

Product Name	4-Amino-5-Ethyl-1-[(2R,3S,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrimidin-2-One
CAS No.	95740-17-3
Molecular Formula	C11H16FN3O4
Molecular Weight	273.26 g/mol
Synonyms	2(1H)-Pyrimidinone, 4-amino-5-ethyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-; 4-Amino-5-ethyl-1-(3-fluoro-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one; Fluorinated Nucleoside Analog; 3'-Fluoro-2'-deoxyribonucleoside derivative; 95740-17-3; Antiviral Nucleoside Intermediate; 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethyl-4-aminopyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical development. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring full traceability and compliance with cGMP standards where required. Specifications can be tailored to meet the specific needs of your research or process development phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.