Description

(D-Ala2)-Dynorphin A (1-9) H-Tyr-D-Ala-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Oh is a synthetic, biologically active nonapeptide analog of the endogenous opioid peptide Dynorphin A. This compound is of significant value for research into the κ-opioid receptor (KOR) system, offering enhanced metabolic stability compared to its native counterpart. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuropharmacology, pain management studies, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A critical tool for studying the physiological and pathological roles of the κ-opioid receptor (KOR) in the central nervous system.
• Pharmacological Assays: Used in in vitro and in vivo models to investigate analgesia, stress responses, mood regulation, and addiction pathways.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the design of new KOR-targeting pharmaceuticals for pain and neuropsychiatric disorders.
• Biochemical Studies: Employed in receptor binding studies, signal transduction experiments, and functional characterization of opioid receptor subtypes.
• Academic & Institutional Research: Fundamental for university and government lab research programs focused on peptide chemistry and neuropeptide function.

Basic Information

Product Name	(D-Ala2)-Dynorphin A (1-9) H-Tyr-D-Ala-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Oh
CAS No.	95673-38-4
Molecular Formula	C53H86N20O11
Molecular Weight	1155.4 g/mol
Synonyms	Dynorphin A (1-9) amide, [D-Ala2]-Dynorphin A (1-9); [D-Ala2]-Dyn A (1-9); H-Tyr-D-Ala-Gly-Phe-Leu-Arg-Arg-Ile-Arg-NH2; (D-Ala2)-Dynorphin A (1-9) amide; Nonapeptide D-Ala2 Dynorphin A fragment; Kappa opioid receptor agonist peptide
EINECS	Contact for details

Quality Control

Our (D-Ala2)-Dynorphin A (1-9) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity, content, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Peptide Content)	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.